Trois contes doubles

Synaptic Ménage à Trois

Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.

Ménage à trois

Quantization of Drinfel’d doubles

Hopf algebra quantizations of 4-dimensional and 6-dimensional real classical Drinfel’d doubles are studied by following a direct “analytic” approach. The full quantization is explicitly obtained for most of the Drinfel’d doubles, except a small number of them for which the dual Lie algebra is either sl2 or so(3). In the latter cases, the classical r-matrices underlying the Drinfel’d double quan...

Shared delusions of doubles.

This is the first report of two partners in a folie à deux situation manifesting identical Capgras delusions. It is postulated that the Capgras syndrome developed as a result of interaction between a dominant patient with primarily paranoid psychopathology and a submissive one with primarily organic dysfunction. The submissive "neuro-organic" partner experienced a non-delusional misidentificati...

Ménage à trois

Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.